Clump Distance to the Magellanic Clouds and Anomalous Colors in the Galactic Bulge

I demonstrate that the two unexpected results in the local Universe: 1) anomalous intrinsic (V-I)_0 colors of the clump giants and RR Lyrae stars in the Galactic center, and 2) very short distances to the Magellanic Clouds (LMC, SMC) as inferred from clump giants, are connected with each other. The (V-I)_0 anomaly is partially resolved by using the photometry from the phase-II of the Optical Gravitational Lensing Experiment (OGLE) rather than phase-I. The need for V- or I-magnitude-based change in the bulge (V-I)_0 is one option to explain the remaining color discrepancy. Such change may originate in a coefficient of selective extinction A_V/E(V-I) smaller than typically assumed. Application of the (V-I)_0 correction (independent of its source) doubles the slope of the absolute magnitude - metallicity relation for clump giants, so that M_I(RC) = -0.23 + 0.19[Fe/H]. Consequently, the estimates of the clump distances to the LMC and SMC are affected. Udalski's (1998c) distance modulus of mu_{LMC} = 18.18 +/- 0.06 increases to mu_{LMC} = 18.27 +/- 0.07. The distance modulus to the SMC increases by 0.12 to mu_{SMC} = 18.77 +/- 0.08. I argue that a more comprehensive assessment of the metallicity effect on M_I(RC) is needed.Comment: accepted by ApJ Letters, brief review of the short distance scale dropped, discussion of the absolute magnitude - metallicity relation for clump giants shortened and made more qualitative, results basically unchange

Can CCM law properly represent all extinction curves?

We present the analysis of a large sample of lines of sight with extinction curves covering wavelength range from near-infrared (NIR) to ultraviolet (UV). We derive total to selective extinction ratios based on the Cardelli, Clayton and Mathis (1989, CCM) law, which is typically used to fit the extinction data both for diffuse and dense interstellar medium. We conclude that the CCM law is able to fit most of the extinction curves in our sample. We divide the remaining lines of sight with peculiar extinction into two groups according to two main behaviors: a) the optical/IR or/and UV wavelength region cannot be reproduced by the CCM formula; b) the optical/NIR and UV extinction data are best fit by the CCM law with different values of R_V. We present examples of such curves. The study of both types of peculiar cases can help us to learn about the physical processes that affect dust in the interstellar medium, e.g., formation of mantles on the surface of grains, evaporation, growing or shattering.Comment: 6 pages, 4 figures, in "Light, dust and chemical evolution", Journal of Physics: Conference Serie

Real-Time Treatment Planning Optimisation for Brachytherapy

In this paper, we present an integrated system for real-time dose distribution calculation and treatment planning optimisation for brachytherapy of prostate cancer, with a special emphasis on the visual integration of the dosimetry and target images obtained from the open magnetic resonance system. This system involves a fast method to calculate dose distributions of multiple concurrent radioactive sources, based on the combination of elements from a database of pre-calculated dose distribution maps for single sources, combined linearly to provide the final dose distribution map. Simulated annealing, in conjunction with the inverse planning method, is used to determine the source dwell times at pre-selected locations in order to optimally irradiate thetumour while preserving the surrounding healthy tissues. This algorithm, implemented in FORTRAN, is integrated into a computer-assisted treatment planning tool, written in JAVA, using the runtime class and RMI API of Java. The whole system is now under clinical testing at the Geneva University Hospital

The Angstrom Project: a microlensing survey of the structure and composition of the bulge of the Andromeda galaxy

The Andromeda Galaxy Stellar Robotic Microlensing Project (The Angstrom Project) aims to use stellar microlensing events to trace the structure and composition of the inner regions of the Andromeda Galaxy (M31). We present microlensing rate and timescale predictions and spatial distributions for stellar and sub-stellar lens populations in combined disk and barred bulge models of M31. We show that at least half of the stellar microlenses in and around the bulge are expected to have characteristic durations between 1 and 10 days, rising to as much as 80% for brown-dwarf dominated mass functions. These short-duration events are mostly missed by current microlensing surveys that are looking for Macho candidates in the M31 dark matter halo. Our models predict that an intensive monitoring survey programme such as Angstrom, which will be able to detect events of durations upwards of a day, could detect around 30 events per season within ~5 arcminutes of the M31 centre, due to ordinary low-mass stars and remnants. This yield increases to more than 60 events for brown-dwarf dominated mass functions. The overall number of events and their average duration are sensitive diagnostics of the bulge mass, in particular the contribution of low-mass stars and brown dwarfs. The combination of an inclined disk, an offset bar-like bulge, and differences in the bulge and disk luminosity functions results in a four-way asymmetry in the number of events expected in each quadrant defined by the M31 disk axes. The asymmetry is sensitive to the bar prolongation, orientation and mass.Comment: 9 pages, submitted to MNRA

Decreased expression of breast cancer resistance protein in the duodenum in patients with obstructive cholestasis

Background/Aims: The expression of transporters involved in bile acid homeostasis is differentially regulated during obstructive cholestasis. Since the drug efflux transporter breast cancer resistance protein (BCRP) is known to transport bile acids, we investigated whether duodenal BCRP expression could be altered during cholestasis. Methods: Using real-time RT-PCR analysis we determined mRNA expression levels in duodenal tissue of 19 cholestatic patients. Expression levels were compared to 14 healthy subjects. BCRP protein staining was determined in biopsies of 6 cholestatic and 6 healthy subjects by immunohistochemistry. Results: We found that in patients with obstructive cholestasis mean duodenal BCRP mRNA levels were significantly reduced to 53% and mean protein staining was reduced to 57%. Conclusions: BCRP, a transporter for bile acids and numerous drugs, appears to be down-regulated in the human duodenum during cholestasis. The clinical impact of these results has to be investigated in further studies. Copyright (c) 2006 S. Karger AG, Basel

Endoluminal beta-radiation therapy for the prevention of coronary restenosis after balloon angioplasty.

BACKGROUND: Beta radiation is effective in reducing vascular neointimal proliferation in animals after injury caused by balloon angioplasty. However, the lowest dose that can prevent restenosis after coronary angioplasty has yet to be determined. METHODS: After successful balloon angioplasty of a previously untreated coronary stenosis, 181 patients were randomly assigned to receive 9, 12, 15, or 18 Gy of radiation delivered by a centered yttrium-90 source. Adjunctive stenting was required in 28 percent of the patients. The primary end point was the minimal luminal diameter six months after treatment, as a function of the delivered dose of radiation. RESULTS: At the time of follow-up coronary angiography, the mean minimal luminal diameter was 1.67 mm in the 9-Gy group, 1.76 mm in the 12-Gy group, 1.83 mm in the 15-Gy group, and 1.97 mm in the 18-Gy group (P=0.06 for the comparison of 9 Gy with 18 Gy), resulting in restenosis rates of 29 percent, 21 percent, 16 percent, and 15 percent, respectively (P=0.14 for the comparison of 9 Gy with 18 Gy). At that time, 86 percent of the patients had had no serious cardiac events. In 130 patients treated with balloon angioplasty alone, restenosis rates were 28 percent, 17 percent, 16 percent, and 4 percent, respectively (P=0.02 for the comparison of 9 Gy with 18 Gy). Among these patients, there was a dose-dependent enlargement of the lumen in 28 percent, 50 percent, 45 percent, and 74 percent of patients, respectively (P<0.001 for the comparison of 9 Gy with 18 Gy). The rate of repeated revascularization was 18 percent with 9 Gy and 6 percent with 18 Gy (P=0.26). CONCLUSIONS: Intracoronary beta radiation therapy produces a significant dose-dependent decrease in the rate of restenosis after angioplasty. An 18-Gy dose not only prevents the renarrowing of the lumen typically observed after successful balloon angioplasty, but actually induces luminal enlargement

Evidence for dark matter in the inner Milky Way

The ubiquitous presence of dark matter in the universe is today a central tenet in modern cosmology and astrophysics. Ranging from the smallest galaxies to the observable universe, the evidence for dark matter is compelling in dwarfs, spiral galaxies, galaxy clusters as well as at cosmological scales. However, it has been historically difficult to pin down the dark matter contribution to the total mass density in the Milky Way, particularly in the innermost regions of the Galaxy and in the solar neighbourhood. Here we present an up-to-date compilation of Milky Way rotation curve measurements, and compare it with state-of-the-art baryonic mass distribution models. We show that current data strongly disfavour baryons as the sole contribution to the galactic mass budget, even inside the solar circle. Our findings demonstrate the existence of dark matter in the inner Galaxy while making no assumptions on its distribution. We anticipate that this result will compel new model-independent constraints on the dark matter local density and profile, thus reducing uncertainties on direct and indirect dark matter searches, and will shed new light on the structure and evolution of the Galaxy.Comment: First submitted version of letter published in Nature Physics on Febuary 9, 2015: http://www.nature.com/nphys/journal/vaop/ncurrent/full/nphys3237.htm

Planetary and Other Short Binary Microlensing Events from the MOA Short Event Analysis

We present the analysis of four candidate short duration binary microlensing events from the 2006-2007 MOA Project short event analysis. These events were discovered as a byproduct of an analysis designed to find short timescale single lens events that may be due to free-floating planets. Three of these events are determined to be microlensing events, while the fourth is most likely caused by stellar variability. For each of the three microlensing events, the signal is almost entirely due to a brief caustic feature with little or no lensing attributable mainly to the lens primary. One of these events, MOA-bin-1, is due to a planet, and it is the first example of a planetary event in which stellar host is only detected through binary microlensing effects. The mass ratio and separation are q = 4.9 +- 1.4 x 10^{-3} and s = 2.10 +- 0.05, respectively. A Bayesian analysis based on a standard Galactic model indicates that the planet, MOA-bin-1Lb, has a mass of m_p = 3.7 +- 2.1 M_{Jup}, and orbits a star of M_* = 0.75{+0.33 -0.41} M_solar at a semi-major axis of a = 8.3 {+4.5 -2.7} AU. This is one of the most massive and widest separation planets found by microlensing. The scarcity of such wide separation planets also has implications for interpretation of the isolated planetary mass objects found by this analysis. If we assume that we have been able to detect wide separation planets with a efficiency at least as high as that for isolated planets, then we can set limits on the distribution on planets in wide orbits. In particular, if the entire isolated planet sample found by Sumi et al. (2011) consists of planets bound in wide orbits around stars, we find that it is likely that the median orbital semi-major axis is > 30 AU.Comment: 47 pages with 14 figure

The EROS2 search for microlensing events towards the spiral arms: the complete seven season results

The EROS-2 project has been designed to search for microlensing events towards any dense stellar field. The densest parts of the Galactic spiral arms have been monitored to maximize the microlensing signal expected from the stars of the Galactic disk and bulge. 12.9 million stars have been monitored during 7 seasons towards 4 directions in the Galactic plane, away from the Galactic center. A total of 27 microlensing event candidates have been found. Estimates of the optical depths from the 22 best events are provided. A first order interpretation shows that simple Galactic models with a standard disk and an elongated bulge are in agreement with our observations. We find that the average microlensing optical depth towards the complete EROS-cataloged stars of the spiral arms is $\bar{\tau} =0.51\pm .13\times 10^{-6}$, a number that is stable when the selection criteria are moderately varied. As the EROS catalog is almost complete up to $I_C=18.5$, the optical depth estimated for the sub-sample of bright target stars with $I_C<18.5$ ($\bar{\tau}=0.39\pm >.11\times 10^{-6}$) is easier to interpret. The set of microlensing events that we have observed is consistent with a simple Galactic model. A more precise interpretation would require either a better knowledge of the distance distribution of the target stars, or a simulation based on a Galactic model. For this purpose, we define and discuss the concept of optical depth for a given catalog or for a limiting magnitude.Comment: 22 pages submitted to Astronomy & Astrophysic

The MACHO Project 9 Million Star Color-Magnitude Diagram of the Large Magellanic Cloud

We present a 9 million star color-magnitude diagram (9M CMD) of the LMC bar. The 9M CMD reveals a complex superposition of different age and metallicity stellar populations, with important stellar evolutionary phases occurring over 3 orders of magnitude in number density. First, we count the non-variable supergiants, the associated Cepheids, and measure the effective temperatures defining the instability strip. Lifetime predictions of stellar evolution theory are tested, with implications for the origin of low-luminosity Cepheids. The highly-evolved AGB stars have a bimodal distribution in brightness, which we interpret as discrete old populations (>1 Gyr). The faint AGB may be metal-poor and very old. We identify the clusters NGC 411 and M3 as templates for the admixture of old stellar populations. However, there are indications that the old and metal-poor field population has a red HB morphology: the RR Lyraes lie on the red edge of the instability strip, the AGB-bump is very red, and the ratio of AGB-bump stars to RR Lyraes is quite large. If the HB second parameter is age, the old and metal-poor field population likely formed after the oldest clusters. Lifetime predictions of stellar evolution theory lead us to associate a significant fraction of the red HB clump giants with the same old and metal-poor population producing the RR Lyraes and the AGB-bump. In this case, compared to the age-dependent luminosity predictions of stellar evolution theory, the red HB clump is too bright relative to the RR Lyraes and AGB-bump. Last, the surface density profile of RR Lyraes is fit by an exponential, favoring a disk-like rather than spheroidal distribution. We conclude that the age of the LMC disk is probably similar to the age of the Galactic disk. (ABRIDGED)Comment: to appear in the Astronomical Journal, 49 pages, 12 figures, aaspp4.st